excis

VETCARE ^ÔVETERINARY PRODUCTS

PARASITICIDE

AQUAHEALTH ^ÔDIAGNOSTIC SERVICES

Cypermrthrin 1% w/v (cis 40 : trans 60)

TREATMENT AGAINST SEA-LICE

Presentation: A clear, yellow tinted solution for dilution with water, with an alcoholic odour containing 1% w/v cypermethrin (cis 40 : trans 60).

Recommended use: Excis is indicated for the treatment and control of sealice in farmed marine fish. It is licensed for use on Atlantic Salmon (Salmo salar) and has been proven safe and effective during laboratory and field trials on Sea Bream (Sparus auratus) and Sea Bass (Dicentrarchus labrax).

Excis will treat and control all stages of sea-lice (class: Crustacea), such as those of the genera: Lepeophtheirus, Ergasilus, Caligus, Lernathropus, Gnathia, Anilocra, Emetha, Nerocila, Ceratothoa.

Manufacturer: Vericore Ltd; a wholly owned company by Novartis Animal Vaccines Ltd., UK.

Dosage and administration: Preparation of the sea-cage to be treated: The sea-cage net should be raised to a depth of 2–2.5 metres, and then surrounded by impervious tarpaulins to isolate the cage to be treated. The depth of enclosed water should then be 3 metres (i.e. there should be some space at around 0.5-1m between the net bottom and the tarpaulin). An oxygen diffuser should be used during treatment to maintain an oxygen level greater than 7mg/l.

The product is administered by addition to seawater: Immediately prior to administration, the correct volume of product is mixed with approximately 40 litres of seawater before adding to the prepared sea-cage at several locations to ensure maximum dispersion.

Treatment Period: 1 hour.

Treatment Dose: 1ml Excis/m³ sea water, which is equivalent to 10µg cypermethrin/litre sea water (10ppb). The amount of product to achieve the treatment dose can be calculated using the table below:

SEA LICE TREATMENT TABLE
Cage type/size	Surface (m²)	Treatment depth (m) *	Volume (m³)	EXCIS (ml)	EXCIS bottles (x 200ml)
6m x 6m rectangular	36	3	108	108	0.54
7m x 7m rectangular	49	3	147	147	0.735
10m x 10m rectangular	100	3	300	300	1.5
12m x 12m rectangular	144	3	432	432	2.16
15m x 15m rectangular	225	3	675	675	3.375
16m x 16m rectangular	256	3	768	768	3.84
24m x 24m rectangular	576	3	1728	1728	8.64
30m circumference	72	3	215	215	1.075
40m circumference	127	3	382	382	1.91
50m circumference	199	3	597	597	2.985
60m circumference	286	3	858	858	4.29
70m circumference	390	3	1170	1170	5.85
80m circumference	510	3	1530	1530	7.65
90m circumference	645	3	1935	1935	9.675
100m circumference	796	3	2388	2388	11.94

* recommended treatment depth

The fish should be appropriately starved in order to ensure an empty gastrointestinal tract. Such practice relieves much of the handling stress. The oxygen levels and the behaviour of the fish should be continuously monitored during treatment. If there is any sudden decrease in the oxygen levels, the tarpaulin should be dropped immediately. Otherwise the treatment continues for 1 hour.

At the end of the treatment period the tarpaulin and equipment should be removed and the nets lowered to their normal depth.

Mild transient headshaking/flashing/uncoordinated swimming have been occasionally reported in salmon. There have been no permanent effects, no mortalities and all fish were normal within hours of treatment.

Further guidelines: Treatment of sea lice in marine aquaculture should aim at reducing the presence of gravid female lice among the cultured fish. Therefore, if no treatment has been previously attempted, those fish with a high infestation rate by mature lice should be treated first. Thereafter the fish should be treated before the lice establish on them and reach reproductive stage. This strategy should help to reduce the number of free-swimming, infective stages released mainly during the warmer seasons and is recommended. The treatment may be repeated when signs of re-infestation occur. A strategic approach to sea-lice control with Excis should slow down re-infestation rate and increase the interval between treatments.

Contra-indications, warnings, withdrawal period: Fish may be harvested for human consumption no less than 24 hours after the last treatment. The recommended dosage should not be exceeded. No interactions with other medicaments are known.

Pharmaceutical precautions: For animal treatment only. Use under veterinary direction. Keep out of reach of children.

Operator Warnings: Wear protective clothing, i.e. overalls, eye protection, rubber or neoprene gloves, (0.3mm thick) and a disposable face mask when handling the product and tarpaulins or nets of treated cages. Do not smoke, drink or eat while handling the product. Avoid contact with the skin, eyes, nose and mouth. If clothing becomes contaminated remove without delay and wash skin thoroughly with soap and water. Change out of protective clothing and wash hands thoroughly after using the product. Launder protective clothing before re-use.

The product is of low hazard by oral and dermal routes. Inhalation of product may cause irritation to the mucous membranes and respiratory tract. Skin exposure may cause transient sensations (tingling, numbness) which disappear after a few hours. Obtain medical advice if symptoms persist.

Highly flammable

Environmental Warnings: In its concentrated form, the product may present a danger to other aquatic life. Prevent any unnecessary release of the product into the marine environment, do not contaminate surface waters or ditches with product, used containers, or the rinsing and do not reuse the container for any purpose. Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.

Packaging: High density polyethylene bottles containing 200ml of product, 15 bottles in a pack. The bottles are designed to float should these be dropped accidentally.

Storage: Do not store above 25ºC, protect from light. Store in the original container and keep the container tightly closed after use. The product will remain stable for 12 months from manufacture. Once opened the contents must be used within one month or discarded.

Legal category: Prescription only medicine (POM).

USEFUL CALCULATIONS FOR CIRCULAR CAGES

Radius (R); Depth (H);

Diameter (D) = 2xR

Circumference (C) = 2xΠxR = 6.28xR

Radius (R) = C/(2xΠ) = C/6.28

Surface Area (S) = ΠxR² = 3.14xR²

Volume (V) = SxH = ΠxR²xH = 3.14xR²xH

Example: C=70m circular cage with 3m treatment depth

R = 70/(3.14x2) = 11.15 m S = 3.14 x(11.15)² = 390.4 m² V = 390.4x3 = 1171 m³